Effects of Low Temperature Plasma on Prostate Cancer Cells Using the Bovie® Medical J-Plasma® Device
Nazir Barekzi, Mounir Laroussi, Greg Konesky, Shawn Roman
This basic research study using low temperature plasma generated by the J-Plasma system, studied the therapeutic effects against the DU145 prostate cancer cell line. The DU145 cells in complete culture media were treated with different exposure times and different J-Plasma system parameters. The optimum settings of the J-Plasma system were identified based on the cancer cell viability at 0, 12, 24, 48, and 72 h post-low temperature plasma treatments. The results indicate that J-Plasma killing and cell viability was exposure time dependent and induced a reduction in cell proliferation and delayed killing effect.
APYX® MEDICAL DISCLOSURES:
This work was supported by Bovie Medical (now Apyx Medical). Barekzi & Laroussi provided consulting work for this preclinical study. Greg Konesky at the time of publication was an employee of Bovie Medical. Shawn Roman is an employee of Apyx Medical.
CLEARED INDICATIONS & MANUFACTURING DISCLOSURES
- Apyx Medical wants to present you with current scientific discourse. Specific usage outside of the general cleared indication may not be safe or effective. Renuvion®/J- Plasma has received a general clearance and has not been determined to be safe or effective for use in any specific indication or anatomical location.
- Apyx Medical manufactures and owns the Renuvion/J-Plasma technology discussed in this article.
Risks associated with the use of J-Plasma may include: Helium embolism due to insufflation of gas into the surgical site or due to inadvertent introduction into the venous or arterial blood supply system; ineffective hemostasis; infection of the treatment site post-treatment; unintended injury (burn, scarring, increased healing time) due to excessive treatment; pneumothorax, hematoma, pain, erythema, edema, or bleeding. As with all energy devices there are inherent risks associated with its use, refer to the IFU for further information.
INTENDED USE DISCLOSURE
The Renuvion/J-Plasma Precise Open® Handpiece is intended to be used with compatible J-Plasma electrosurgical generators for the delivery of radiofrequency energy and/or helium plasma for cutting, coagulation and ablation of soft tissue during open surgical procedures. The Renuvion/J-Plasma Precise & Precise Open Handpieces are compatible with electrosurgical Generators BVX-200H, and BVX-200P. Refer to the Instructions for Use for the currently approved or cleared indications.