Effects of Low Temperature Plasma on Prostate Cancer Cells Using the Bovie® Medical J-Plasma® Device


Journal Article


Nazir Barekzi, Mounir Laroussi, Greg Konesky, Shawn Roman


This basic research study using low temperature plasma generated by the J-Plasma system, studied the therapeutic effects against the DU145 prostate cancer cell line. The DU145 cells in complete culture media were treated with different exposure times and different J-Plasma system parameters. The optimum settings of the J-Plasma system were identified based on the cancer cell viability at 0, 12, 24, 48, and 72 h post-low temperature plasma treatments. The results indicate that J-Plasma killing and cell viability was exposure time dependent and induced a reduction in cell proliferation and delayed killing effect.


This work was supported by Bovie Medical (now Apyx Medical). Barekzi & Laroussi provided consulting work for this preclinical study. Greg Konesky at the time of publication was an employee of Bovie Medical. Shawn Roman is an employee of Apyx Medical.


  • Apyx Medical wants to present you with current scientific discourse. Specific usage outside of the general cleared indication may not be safe or effective. Renuvion®/J- Plasma has received a general clearance and has not been determined to be safe or effective for use in any specific indication or anatomical location.
  • Apyx Medical manufactures and owns the Renuvion/J-Plasma technology discussed in this article.

Risks associated with the use of J-Plasma may include: Helium embolism due to insufflation of gas into the surgical site or due to inadvertent introduction into the venous or arterial blood supply system; ineffective hemostasis; infection of the treatment site post-treatment; unintended injury (burn, scarring, increased healing time) due to excessive treatment; pneumothorax, hematoma, pain, erythema, edema, or bleeding. As with all energy devices there are inherent risks associated with its use, refer to the IFU for further information.

The Renuvion/J-Plasma Precise Open® Handpiece is intended to be used with compatible J-Plasma electrosurgical generators for the delivery of radiofrequency energy and/or helium plasma for cutting, coagulation and ablation of soft tissue during open surgical procedures. The Renuvion/J-Plasma Precise & Precise Open Handpieces are compatible with electrosurgical Generators BVX-200H, and BVX-200P. Refer to the Instructions for Use for the currently approved or cleared indications.